M. Madan Babu – Group leader
Madan’s research interest is to understand how regulation is achieved in cellular systems at multiple levels of complexity and how this influences evolvability of genomes. His research program is primarily funded by the Medical Research Council. Please see Research and About Madan for more details.
Xiaohan Li – Postdoc
Xiaohan is interested in discovery of short linear motifs involved in function of intrinsically disordered domains, with focus on intracellular functional and dysfunctional assemblies and membraneless organelles. The work will provide insight into our understanding of sequence-to-function diagram for disordered proteins and regions. Xiaohan got his PhD in biophysical chemistry from Yale University studying how the interaction between intrinsically disordered protein tau and tubulin contributes to tau’s function.
Pavithra Lakshminarasimhan – Investigator Scientist
Pavi’s research interests are to understand cell cycle regulatory mechanisms in disease and development, with emphasis on protein localisation. In Madan’s lab, her research aims at discovering how compositionally unique segments in the proteome (disordered and /or repeats) affect proteostasis. She was awarded Ph.D. by University of Pune for her work done at National Centre for Cell Science, India. Before joining the group, she was a post-doctoral fellow at University of Cambridge Cancer Research UK- Cambridge Institute. She is an currently an Investigator Scientist with Madan on his ERC grant.
Alex Gunnarsson – PhD student
Alex is interested in how short linear motifs within protein intrinsic disorder allow cells to process co mplex information and to regulate cellular decision making. The aim of his research is to characterise how the motifs evolve and change over time and how this process enables functional adaptation through motif-mediated network rewiring. Alex obtained a BA and MSci in Biochemistry from the University of Cambridge working on super resolution image analysis and cryo-EM method development respectively. His work is funded by the MRC LMB.
Andal Murthy – Investigator Scientist
Andal’s research aims to understand the role of tRNA regulation in controlling protein expression level and how this impacts genome scale protein abundance, cellular phenotypes and disease. She obtained her PhD from the Department of Biochemistry, University of Cambridge and is currently an investigator scientist in the group. Before joining the group, Andal was an investigator scientist in Dr Simon Bullock’s lab at the MRC-LMB.
Rita Pancsa – Postdoc
Rita investigates the functional benefits of regulated protein unfolding leading to the exposure of cryptic disordered regions. She obtained her PhD at the Free University of Brussels for her research on intrinsically disordered proteins. Rita is currently awarded with an EMBO long-term fellowship.
Sreenivas Chavali – Investigator Scientist
Sreeni leads a research programme aimed at understanding how tandem repeats and low complexity sequences influence phenotypes by affecting different cellular processes, with special emphasis on human diseases. He was awarded a Ph.D. by University of Pune for his work done at CSIR Institute of Genomics and Integrative Biology, India. Before joining the group, he was a post-doctoral fellow at University of Gothenburg, Sweden. He joined the group as a Career Development Fellow and subsequently was an EMBO long term fellow. Currently, he is an MRC Investigator Scientist and a Junior Research Fellow at Wolfson College, University of Cambridge.
Melis Kayikci – Scientific Manager
Melis has been developing a webserver, aimed at helping structural biologists to analyze and visualize protein structures at atomic resolution via a residue-residue interaction networks approach. She also oversees various scientific administrative responsibilities within the group in addition to providing scientific support with computing and research. Melis did her MRes in Computational Biology at the University of York before completing her PhD on microarray analysis of RNA-binding proteins in MRC, Laboratory of Molecular Biology in 2011.
Charles Ravarani – Postdoc
Charles is working on how the transcriptional machinery assembles in the nucleosomal context, and how this can influnence gene expression characteristics such as noise. He has studied Biochemistry at the University of Edinburgh before completing his MPhil in Computational Biology at the University of Cambridge.
Robert Weatheritt – Postdoc
Robert’s main interest is understanding how mRNA regulation impacts on proteomic diversity. His present work focuses, in particular, on mRNA localisation and alternative splicing. He received his PhD from the EMBL-Heidelberg for work investigating linear motif biology.
Alexey Morgunov – PhD student
Alexey is interested in the coevolution of tRNAs, codons and the tRNA associated proteins, and how tRNAs control translation and shape the genetic code. He studied Biochemistry and Systems Biology at Trinity College, University of Cambridge with research experience in directed evolution and synthetic biology of unnatural amino acids and synthetic genetic polymers. His work is supported by the MRC LMB.
Hannes Harbrecht – PhD student
Hannes’ research focusses on computational structural biology. His interest is to understand and improve the modelling of the molecular forces that keep proteins folded and unfolded and form the basis of signal transduction and intermolecular interaction in the cell. Hannes holds an MPhil in Computational Biology and an MSc in Theoretical Chemistry. His research is supported by the Medical Research Council.