Madan’s research interest is to understand how regulation is achieved in cellular systems at multiple levels of complexity and how this influences evolvability of genomes. His research program is primarily funded by the Medical Research Council. Please see Research and About Madan for more details.
Daniel’s project aims to shed light on the biogenesis of polytopic membrane proteins such as G-protein coupled receptors (GPCRs); how the emerging polypeptide inserts into the lipid bilayer, adapts a functional conformation and is eventually expressed at the cell’s surface. He employs an interdisciplinary computational approach investigating the structural, biophysical and genomic signatures associated with GPCR folding, function and misfolding. Daniel received a Master’s degree in Molecular Biophysics from King’s College London and conducted research as a Postgraduate Research Fellow at the Yale School of Medicine before joining the group.
Yonathan’s research aims to understand the extent of heterogeneity in the cellular machinery that is involved in the production and degradation of proteins. The aim of this project is to understand how variation in sequence and composition of molecular machines involved in these processes affects the regulation of proteins in the cell. Yonathan obtained his PhD in Biophysics from the University of Maryland College Park where he worked on the biophysics of motor proteins. He is currently an EMBO long-term fellow.
Alex is interested in how short linear motifs within protein intrinsic disorder allow cells to process complex information and to regulate cellular decision making. The aim of his research is to characterise how the motifs evolve and change over time and how this process enables functional adaptation through motif-mediated network rewiring. Alex obtained a BA and MSci in Biochemistry from the University of Cambridge working on super resolution image analysis and cryo-EM method development respectively. His work is funded by the MRC LMB.
Hannes’ research focusses on computational structural biology. His interest is to understand and improve the modelling of the molecular forces that keep proteins folded and unfolded and form the basis of signal transduction and intermolecular interaction in the cell. Hannes holds an MPhil in Computational Biology and an MSc in Theoretical Chemistry. His research is supported by the Medical Research Council.
Alissa is interested in the molecular determinants governing protein-protein/ligand interactions and how these interactions induce functionally important conformational changes. In her current work, she is applying an integrative bioinformatic approach to the study of G-protein coupled receptors (GPCRs), a highly relevant class of drug targets. Alissa obtained an MSci in Biochemistry from the University of Oxford. Her work is funded by the Medical Research Council.
Xiaohan is interested in discovery of short linear motifs involved in function of intrinsically disordered domains, with focus on intracellular functional and dysfunctional assemblies and membraneless organelles. The work will provide insight into our understanding of sequence-to-function diagram for disordered proteins and regions. Xiaohan got his PhD in biophysical chemistry from Yale University studying how the interaction between intrinsically disordered protein tau and tubulin contributes to tau’s function.
Maria’s research is focused on understanding how membrane protein structural variation results in functional diversity. In her current work, she employs computational systems biology to explore how membrane protein structural, spatial and interindividual changes can result in differences in physiology and drug response. Maria did her PhD in Biomedicine at the Pompeu Fabra University in Barcelona. Before joining the group, she was a post-doctoral researcher at the Philipps University Marburg, Germany. She initially joined the MRC LMB supported by a FEBS Long-Term Postdoctoral Fellowship and is currently a Marie Skłodowska-Curie Fellow.
Alexey is interested in the coevolution of tRNAs, codons and the tRNA associated proteins, and how tRNAs control translation and shape the genetic code. He studied Biochemistry and Systems Biology at Trinity College, University of Cambridge with research experience in directed evolution and synthetic biology of unnatural amino acids and synthetic genetic polymers. His work is supported by the MRC LMB.
Andal’s research aims to understand the role of tRNA regulation in controlling protein expression level and how this impacts genome scale protein abundance, cellular phenotypes and disease. She obtained her PhD from the Department of Biochemistry, University of Cambridge and is currently an investigator scientist in the group. Before joining the group, Andal was an investigator scientist in Dr Simon Bullock’s lab at the MRC-LMB.
Greg is an AstraZeneca-funded postdoc working on elucidating the role of alternative splicing in healthy tissue and in disease, focusing on prostate cancer. Originally trained as a computer scientist, Greg obtained an MSc in Systems Biology while in the group of Chris Workman at the Technical University of Denmark. He then completed a PhD in Molecular Evolution with Nick Goldman at EMBL-EBI, and continues to be interested in evolutionary aspects of the biological systems he studies. Before joining Madan’s lab, Greg spent one year as a postdoc in the lab of Leo James at the LMB.