Author Archives: madanm

Melis Kayikci is our group’s Scientific Manager

Many congratulations to Dr. Melis Kayikci, who has been officially promoted to become our group’s Scientific Manager from the 1st of April 2014! Melis will now oversee various scientific administrative responsibilities in our group in addition to providing scientific support … Continue reading

Posted in News about group member | Comments Off

Our perspective on the hidden codes that constrain protein evolution is published in Science

In this essay, we discuss how regulatory elements within protein-coding regions (such as transcription factor binding) can influence codon choice and amino acid preference that are independent of protein structure or function. We discuss how there may be conflicts between … Continue reading

Posted in Research papers | Comments Off

Congratulations to Tilman Flock

Tilman Flock has been awarded the BIF Fellowship. The Boehringer Ingelheim Fonds awards PhD fellowships to outstanding junior scientists who wish to pursue an ambitious PhD project of approximately 3 years in basic biomedical research in an internationally leading laboratory.

Posted in Awards/Distinctions | Comments Off

Molecular signatures of G-protein-coupled receptors published in Nature

In this work, we objectively compare known structures and reveal key similarities and differences among diverse GPCRs. We identify a consensus structural scaffold of GPCRs that is constituted by a network of non-covalent contacts between residues on the transmembrane helices. … Continue reading

Posted in Research papers | Comments Off

Network based approach to study DNA-DNA contacts published in Nucleic Acids Research

In this paper, we present a general statistical framework that is widely applicable to the analysis of genomic contact maps, irrespective of the data acquisition and normalization processes. Within this framework DNA–DNA contact data are represented as a complex network … Continue reading

Posted in Research papers | Comments Off

Strategies to control functional and non-functional aggregation published in Cell Reports

Growing evidence suggests that aggregation-prone proteins are both harmful and functional for a cell. How do cellular systems balance the detrimental and beneficial effect of protein aggregation? In this work, we reveal that aggregation-prone proteins are subject to differential transcriptional, … Continue reading

Posted in Research papers | Comments Off

Perspective on Intrinsically Disordered Regions published in Science

In this perspective piece, we discuss the notion that disordered regions are largely passive is being actively challenged by the idea that they perform diverse functions. We also discuss how the synergy between structured and disordered regions expands the functional … Continue reading

Posted in Research papers | Comments Off

Welcome to Balaji Santhanam!

Dr. Balaji Santhanam from Harvard University has just started as a new Senior Investigator Scientist at the LMB. A very warm welcome from all of us Balaji. We are looking forward to some very exciting discussions and science in the … Continue reading

Posted in Welcome | Comments Off

Welcome to Elisabetta and James!

Elisabetta and James are our two new summer students who started this month. A very warm welcome to both of you and we look forward to some exciting science in the next couple of months!

Posted in Welcome | Leave a comment

Collaborative research with Sarah Teichmann’s group published in Molecular Cell

Through a systematic effort that integrated multiple genome-scale datasets describing various aspects of DNA binding proteins, we show that activators tend to have binding site similarity to nucleosomal histones, resulting in competition for binding to DNA, while repressors show the … Continue reading

Posted in Research papers | Leave a comment