Author Archives: madanm
Many congratulations to Dr. Melis Kayikci, who has been officially promoted to become our group’s Scientific Manager from the 1st of April 2014! Melis will now oversee various scientific administrative responsibilities in our group in addition to providing scientific support … Continue reading
In this essay, we discuss how regulatory elements within protein-coding regions (such as transcription factor binding) can influence codon choice and amino acid preference that are independent of protein structure or function. We discuss how there may be conflicts between … Continue reading
Tilman Flock has been awarded the BIF Fellowship. The Boehringer Ingelheim Fonds awards PhD fellowships to outstanding junior scientists who wish to pursue an ambitious PhD project of approximately 3 years in basic biomedical research in an internationally leading laboratory.
In this work, we objectively compare known structures and reveal key similarities and differences among diverse GPCRs. We identify a consensus structural scaffold of GPCRs that is constituted by a network of non-covalent contacts between residues on the transmembrane helices. … Continue reading
In this paper, we present a general statistical framework that is widely applicable to the analysis of genomic contact maps, irrespective of the data acquisition and normalization processes. Within this framework DNA–DNA contact data are represented as a complex network … Continue reading
Growing evidence suggests that aggregation-prone proteins are both harmful and functional for a cell. How do cellular systems balance the detrimental and beneficial effect of protein aggregation? In this work, we reveal that aggregation-prone proteins are subject to differential transcriptional, … Continue reading
In this perspective piece, we discuss the notion that disordered regions are largely passive is being actively challenged by the idea that they perform diverse functions. We also discuss how the synergy between structured and disordered regions expands the functional … Continue reading
Dr. Balaji Santhanam from Harvard University has just started as a new Senior Investigator Scientist at the LMB. A very warm welcome from all of us Balaji. We are looking forward to some very exciting discussions and science in the … Continue reading
Elisabetta and James are our two new summer students who started this month. A very warm welcome to both of you and we look forward to some exciting science in the next couple of months!
Through a systematic effort that integrated multiple genome-scale datasets describing various aspects of DNA binding proteins, we show that activators tend to have binding site similarity to nucleosomal histones, resulting in competition for binding to DNA, while repressors show the … Continue reading