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A large segment of the proteome consists of disordered regions, yet in most cases, little is known about their mechanisms and functions. What are the roles of protein disorder in cell biology, and how do intrinsically disordered proteins function? These … Continue reading
Gene fusions are common cancer-causing mutations, but the molecular principles by which fusion protein products affect interaction networks and cause disease are not well understood. Here, we perform an integrative analysis of the structural, interactomic, and regulatory properties of thousands … Continue reading
Class A G-protein-coupled receptors (GPCRs) are a large family of membrane proteins that mediate a wide variety of physiological functions, including vision, neurotransmission and immune responses. They are the targets of nearly one-third of all prescribed medicinal drugs such as … Continue reading
The proteasome has pronounced preferences for the amino acid sequence of its substrates at the site where it initiates degradation. Here, we report that modulating these sequences can tune the steady-state abundance of proteins over 2 orders of magnitude in … Continue reading
EMBO elects new members annually on the basis of scientific excellence and outstanding research contributions. The organisation promotes excellence in life sciences by supporting talented researchers, and stimulating exchange of scientific information. Madan, along with 57 other researchers, joins more than … Continue reading
Discovering and understanding oncogenic gene fusions through data intensive computational approaches.
Although gene fusions have been recognized as important drivers of cancer for decades, our understanding of the prevalence and function of gene fusions has been revolutionized by the rise of next-generation sequencing, advances in bioinformatics theory and an increasing capacity … Continue reading
Dr Mark Bayfield is a sabbatical visitor from Dept of Biology, York University, Toronto and has joined our group for 5 months to learn techniques in computational biology (data integration and analysis of next generation sequencing data).
Welcome to Andal who has just started as a postdoc in our group.
Cell-to-cell variation in gene expression levels (noise) generates phenotypic diversity and is an important phenomenon in evolution, development and disease. TATA-box binding protein (TBP) is an essential factor that is required at virtually every eukaryotic promoter to initiate transcription. While … Continue reading
Congratulations to our postdoc Rita to be elected as a Fellow of Darwin College!