About Madan

M. Madan Babu, PhD, FRSC  – Visiting Scientist, MRC Laboratory of Molecular Biology, Cambridge, UK

See resume and list of publications here

M. Madan Babu was a programme leader of the Regulatory Genomics and Systems Biology group at the MRC Laboratory of Molecular Biology, Cambridge, UK. He has now moved to St Jude Children’s Research Hospital as an Endowed Chair of Biological Data Science in the Department of Structural Biology and as the Director of the Center for Data Driven Discovery. He is also a visiting scientist at the MRC Lab of Molecular Biology.

Madan’s group investigates how regulation is achieved at multiple levels of complexity in cellular systems and how this influences the evolution of organisms and their genome. Towards this objective, he primarily uses computational approaches, such as sequence analysis, structure analysis and evolutionary analysis, and develops novel integrative approaches, that use expression data, comparative genomics analysis, network analysis, genomic variation and phenotype data. More recently, his group also exploits yeast genetics to uncover the molecular origins of cell-to-cell variation in the expression level of genes in genetically identical cell populations.

He obtained his undergraduate degree in 2001 from the Centre for Biotechnology, Anna University, India with fellowships from the Indian Institute of Science and the Indian Academy of Sciences. He then received an LMB-Cambridge International Fellowship and a Trinity College Research Scholarship to carry out his doctoral research at the Medical Research Council’s Laboratory of Molecular Biology (MRC-LMB) in Cambridge, UK. During this time, he carried out studies on the structure, evolution and dynamics of transcriptional regulatory networks by employing a combination of computational approaches. For this work, he was awarded the Max Perutz Prize for outstanding PhD research in 2004. He subsequently received an NIH International Visiting Fellowship to work at the NCBI, USA where he defined general principles of the organization of biological networks. He returned to the UK to become an independent Group Leader at the MRC Laboratory of Molecular Biology in 2006, was elected as a Schlumberger Research Fellow at Darwin College, Cambridge in 2007 and was appointed as a Programme Leader in 2010.

Madan Babu is an Executive Editor at Nucleic Acids Research, the Chief Editor of Molecular Systems Biology and a member of F1000. He was a Director of Studies at Trinity College, Cambridge (2011-2015), and a member of the HUGO council. He has published over 150 papers, reviews and chapters (h-index: 65) and has received several awards including the Biochemical Society’s Early Career Award (2009), EMBO Young Investigator Award (2010), British Genetics Society’s Balfour Award (2011), Royal Society of Chemistry’s Molecular BioSystems Award (2011), the Biochemical Society’s Colworth Medal (2014), the Lister Prize from the Lister Institute of  Preventive Medicine and the Protein Science Young Investigator Award (2014) from the American Protein Society. Most recently, Madan received the Francis Crick Medal and Lecture (2015) from the Royal Society, the inaugural Blavatnik Life Science Award (2018) and the EMBO Gold Medal (2019). He is an elected member of EMBO (2016) and Fellow of the Royal Society of Chemistry (2017).