Monthly Archives: September 2014

Structured and disordered facets of the GPCR fold

The seven-transmembrane (7TM) helix fold of G-protein coupled receptors (GPCRs) has been adapted for a wide variety of physiologically important signaling functions. Here, we discuss the diversity in the structured and disordered regions of GPCRs based on the recently published … Continue reading

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Intrinsically Disordered Segments Affect Protein Half-Life in the Cell and during Evolution

Precise control of protein turnover is essential for cellular homeostasis. The ubiquitin-proteasome system is well established as a major regulator of protein degradation, but an understanding of how inherent structural features influence the lifetimes of proteins is lacking. We report … Continue reading

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Welcome to Hannes!

Hannes has just started as a PhD student in our lab!

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Dr M. Madan Babu awarded Lister Research Prize

Congratulations to Madan to be awarded the prestigious Lister Research prize this year along with Melina Schuh, another LMB group leader. Madan’s Lister Research Prize has been awarded for his work on dynamics of tRNA abundance and the regulation of … Continue reading

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