Joint research on chromosome organisation and histone modification during senescence published in Molecular Cell

In this work, we show that nuclear rearrangement of repressive histone marks H3K9me3 and H3K27me3 into nonoverlapping structural layers characterizes senescence-associated heterochromatic foci (SAHF) formation in human fibroblasts. The experiments reveal that high-order heterochromatin formation and epigenetic remodeling of the genome can be discrete events. The paper by Chandra et al. can be read here.