Monthly Archives: July 2012

Collaborative research with Sarah Teichmann’s group published in Molecular Cell

Through a systematic effort that integrated multiple genome-scale datasets describing various aspects of DNA binding proteins, we show that activators tend to have binding site similarity to nucleosomal histones, resulting in competition for binding to DNA, while repressors show the … Continue reading

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Joint research on chromosome organisation and histone modification during senescence published in Molecular Cell

In this work, we show that nuclear rearrangement of repressive histone marks H3K9me3 and H3K27me3 into nonoverlapping structural layers characterizes senescence-associated heterochromatic foci (SAHF) formation in human fibroblasts. The experiments reveal that high-order heterochromatin formation and epigenetic remodeling of the … Continue reading

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