Through a systematic effort that integrated multiple genome-scale datasets describing various aspects of DNA binding proteins, we show that activators tend to have binding site similarity to nucleosomal histones, resulting in competition for binding to DNA, while repressors show the opposite trend. You can read the paper here and the LMB press release here.
In this work, we show that nuclear rearrangement of repressive histone marks H3K9me3 and H3K27me3 into nonoverlapping structural layers characterizes senescence-associated heterochromatic foci (SAHF) formation in human fibroblasts. The experiments reveal that high-order heterochromatin formation and epigenetic remodeling of the genome can be discrete events. The paper by Chandra et al. can be read here.