Our work on how tissue-specifically spliced segments can rewire protein interactions through disordered segments has been published in Molecular Cell. This work, which has been carried out over the last three years integrates multiple large-scale dataset to arrive at a general principle on how splicing can rewire interactions. The work received coverage in Nature Reviews Genetics and the Gates Trust. The press release on the LMB website can be read here.
Co-evolving positions within protein sequences have been used as spatial constraints to develop a computational approach for modeling membrane protein structures. In this mini-review, we discuss how co-evolving sites can be exploited for understanding protein structure and function. The paper can be read here.